Article
Mapping epigenetic gene variant dynamics: comparative analysis of frequency, functional impact and trait associations in African and European populations.
Scientific reports - 6 Mar 2026
Sinkala Musalula, Retshabile Gaone, Mpangase Phelelani T, Bamba Salia, Goita Modibo K, Nembaware Victoria, Elsheikh Samar S M, Heckmann Jeannine, Esoh Kevin, Matshaba Mogomotsi, Adebamowo Clement A, Adebamowo Sally N, Amih Ofon Elvis, Landoure Guida, Wonkam Ambroise, Ramsay Michele, Mulder Nicola
Abstract excerpt
Epigenetic modifications influence gene expression levels, impact organismal traits, and play a role in the development of diseases. Therefore, variants in genes involved in epigenetic processes are likely to be important in disease susceptibility, and the frequency of variants may vary between populations with African and European ancestries. Here, we analyse an integrated dataset to define the frequencies,...
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