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Unraveling the interplay of genetic variants and epigenetic signatures in complex traits.

Advances in genetics - 1 Jan 2025

Franco-Gedda Lana Pacheco, Heidor Renato, Horst Maria Aderuza

Abstract excerpt

Complex traits, characterized by their reliance on multiple genetic variants and intricate environmental influences, present a unique challenge in the field of genetics. At the core of complex traits lies the interaction between numerous genetic variants-often polygenic in nature-and their regulation through epigenetic mechanisms. These mechanisms, which include DNA methylation, histone modification, and...

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PMID: 40818853
DOI: 10.1016/bs.adgen.2025.02.004

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