Pleiotropic cardiometabolic effects of the LDLR rs6511720 T allele: an evaluation of genetic risk across metabolic states.

doi:10.1016/j.numecd.2026.104621

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Pleiotropic cardiometabolic effects of the LDLR rs6511720 T allele: an evaluation of genetic risk across metabolic states.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jun 2026

Chermon Danyel, Samra Lydia Abu, Elkayam Noa, Birk Ruth

Abstract excerpt

BACKGROUND AND AIMS: The functional LDLR rs6511720 polymorphism has been implicated in lipid metabolism and cardiometabolic risk. We aimed to investigate its association with clinically relevant Low-Density Lipoprotein cholesterol (LDL-C) threshold (≥130 mg/dL), cardiometabolic burden, and type 2 diabetes mellitus (T2DM), with emphasis on sex-specific effects. METHODS AND RESULTS: A cross-sectional data analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiometabolic Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, LDL

Share to Cross-Sectional Studies

Share to Dyslipidemias

Share to Genetic Pleiotropy

Share to Metabolic Syndrome

Share to Receptors, LDL

Share to Sex Factors

Source

Open in PubMed

Identifiers

PMID: 41791911
DOI: 10.1016/j.numecd.2026.104621

Genes

LDLR
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pleiotropic cardiometabolic effects of the LDLR rs6511720 T allele: an evaluation of genetic risk across metabolic states.PMID 41791911Read ↗

Genetic and Anthropometric Interplay: How Waist-to-Hip Ratio Modulates LDL-c Levels in Mexican Population.Semantic proximity Read ↗

Investigation of the characteristics of LDLR gene rs688 polymorphism and its association with dyslipidemia in patients at high to very high cardiovascular risk.Semantic proximity Read ↗

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current EvidenceSemantic proximity Read ↗

Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.Semantic proximity Read ↗

Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction.Semantic proximity Read ↗

Genetic polymorphisms associated with metabolic dysfunction-associated steatotic liver disease and cardiometabolic risk susceptibility in the Chinese Han population.Semantic proximity Read ↗

Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in BrazilSemantic proximity Read ↗

Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.Semantic proximity Read ↗

Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants.Semantic proximity Read ↗

Genetics of Triglyceride-Rich Lipoproteins Guide Identification of Pharmacotherapy for Cardiovascular Risk Reduction.Semantic proximity Read ↗

LEP, LDLR and APOA4 gene polymorphisms and their relationship with the risk of overweight, obesity and chronic diseases in adults of the State of Sucre, Venezuela.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.