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Article

Context-Dependent Associations of the APOA1 rs670 Polymorphism with Apolipoprotein A1 and HDL Cholesterol: A Systematic Review and Meta-Analysis.

International journal of molecular sciences - 25 Aug 2026

Chan Chien-Yi, Huang Yi-Chen, Lee Ming-Fen, Huang Chun-Yin, Wu Wen-Chieh

Abstract excerpt

The APOA1 rs670 (-75 G>A) polymorphism has been implicated in lipid metabolism and susceptibility to metabolic syndrome (MetS). However, individual studies have reported inconsistent associations with circulating apolipoprotein A1 (Apo A1) and lipid parameters, and no meta-analysis has comprehensively evaluated these associations stratified by metabolic disorder status. We therefore quantified the associations...

Read the complete abstract on PubMed

Topics

Humans
Apolipoprotein A-I
Cholesterol, HDL
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Metabolic Syndrome

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42737522
DOI: 10.3390/ijms27177622
PMCID: PMC13566318

Genes

APOA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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