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Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles

2025-03-03

Abstract excerpt

<h4>INTRODUCTION</h4> While hallmarked by the accumulation of β-amyloid plaques (Aβ) and neurofibrillary tangles (tau) in the brain, Alzheimer’s disease (AD) is a multifactorial disorder that involves additional pathological events, including neuroinflammation, neurodegeneration and synaptic dysfunction. AD-associated biomolecular changes seem to be attenuated in carriers of the functionally advantageous variant o...

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Literature Corpus work
805959e6-ccd9-58ac-9e99-aa6d434269fb
DOI
10.1101/2025.02.27.25323056
Open publication

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Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profilesDOI 10.1101/2025.02.27.25323056
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