Epigenetic corepressor BCORL1 predominates as a driver of clonal hematopoiesis of indeterminate potential in patients undergoing chronic hemodialysis: a multicenter cohort study.

Abstract excerpt

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant condition characterized by somatic mutations in hematopoietic stem cells in the absence of hematologic malignancy. CHIP predominantly affects older adults and is associated with increased risks of hematologic malignancy, cardiovascular events, and all-cause mortality. However, data on the prevalence, mutational spectrum, and...

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