Pleiotropic roles of elongation factor P in Bacillus subtilis physiology revealed by phenotypic and multi-omics analyses.

Abstract excerpt

Elongation factor P (EF-P) is conserved across the three kingdoms and alleviates ribosome stalling at the XPPX motif of a protein. A genome-wide ribosome-stalling atlas was previously created for the ancestral strain NCIB3610. However, reportedly, ribosome-stalling does not always decrease protein levels. To determine changes in protein levels in the efp mutant, we performed a proteomic analysis of the laboratory...

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