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Article

Keratinocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Genetic Signature of Psoriasis Disease.

Stem cells and development - 1 Apr 2020

Ali Gowher, Elsayed Ahmed K, Nandakumar Manjula, Bashir Mohammed, Younis Ihab, Abu Aqel Yasmin, Memon Bushra, Temanni Ramzi, Abubaker Fadhil, Taheri Shahrad, Abdelalim Essam M

Abstract excerpt

Psoriasis is characterized by hyperproliferation and defective differentiation of keratinocytes (KCs). Patients with psoriasis are at a high risk of developing diabetes and cardiovascular diseases. The debate on the genetic origin of psoriasis pathogenesis remains unresolved due to lack of suitable in vitro human models mimicking the disease phenotypes. In this study, we provide the first human induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31996098
DOI: 10.1089/scd.2019.0150
PMCID: PMC7153648

Genes

DSG1
GDF15
IRS2
IVL
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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