Article

Mitochondrial replacement in an iPSC model of Leber’s hereditary optic neuropathy

2017-03-26

Abstract excerpt

Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrates increased cell death in LHON-RGCs and can be rescued in cybrid corrected RGCs.

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Literature Corpus work: 19d4aba8-f6fa-5720-8018-3538d6c735bc
DOI: 10.1101/120659

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