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[Clinical research progress of gene therapy for Leber hereditary optic neuropathy].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology - 11 Aug 2018

Wu Y J, Li W S

Abstract excerpt

Leber hereditary optic neuropathy (LHON) is a mitochondria hereditary eye disease that involves with retinal ganglion cells (RGCs) resulting eventually in degeneration and atrophy of optic nerve. The three mitochondrial DNA mutations (ND4 G11778A, ND1G3460A, ND6T14484C) have been recognized as the primary mutation locus of LHON. Currently there is no effective therapy for LHON. The result of a clinical trial...

Topics

DNA, Mitochondrial
Dependovirus
Genetic Therapy
Humans
Mutation
NADH Dehydrogenase
Optic Atrophy, Hereditary, Leber

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30107658
DOI: 10.3760/cma.j.issn.0412-4081.2018.08.017

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