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Article

Thyroid dysfunction and Research Domain Criteria framework-based depression phenotypes: Insights from a historical longitudinal cohort.

Journal of affective disorders - 15 Jul 2026

Kumar Rakesh, Pazdernik Vanessa K, Stan Marius N, Sundaresh Vishnu, Frye Mark A, Singh Balwinder

Abstract excerpt

BACKGROUND: Depression is a clinically heterogeneous disorder, making it difficult to identify its biological underpinnings, including potential links to dysregulation of the hypothalamic-pituitary-thyroid axis, which plays a central role in the pathophysiology of depression. The Research Domain Criteria (RDoC) framework provides a multi-dimensional approach to parsing depressive phenotypes. This study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41763325
DOI: 10.1016/j.jad.2026.121526
PMCID: PMC13182770

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AR
CS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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