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Article

Depression phenotypes informed by the RDoC framework using the Patient Health Questionnaire-9: A retrospective study in Peru.

Spanish journal of psychiatry and mental health - 1 Jan 2026

Flores-Cohaila Javier A, Huarcaya-Victoria Jeff, Copaja-Corzo Cesar

Abstract excerpt

BACKGROUND: Traditional approaches treat depression as unidimensional constructs rather than neurobiologically informed symptom clusters. The objective to investigate how Research Domain of Criteria-informed depression assessment enhances phenotype identification compared to traditional factor structures using nationally representative Peruvian data. METHODS: A cross-sectional analysis of Peru's National Health...

Read the complete abstract on PubMed

Topics

Humans
Peru
Phenotype
Female
Cross-Sectional Studies
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Male

Patient Health Questionnaire

Middle Aged

Depression

Factor Analysis, Statistical

Depressive Disorder

Young Adult

Adolescent

Source

Identifiers

PMID: 41619940
DOI: 10.1016/j.sjpmh.2025.11.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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