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Article

Could thyrotropin serum level characterize major depressive disorder phenotype? A systematic review and meta-analysis.

Journal of endocrinological investigation - 1 Apr 2026

Gatta Elisa, Maltese Virginia, Ugoccioni Massimiliano, Silvestrini Irene, Corvaglia Sara, Vetrugno Simone, Ceraso Anna, Vita Antonio, Rotondi Mario, Cappelli Carlo

Abstract excerpt

PURPOSE: Aim of this systematic review is to evaluate if and how thyrotropin (TSH) serum level levels may influence major depressive disorders (MDD) in drug naïve patients, and if it could characterize MDD phenotype. METHODS: A PubMed/MEDLINE, Scopus and Web of Science databases was researched up to January 2025. The studies eligible addressed the questions define based on the PICO framework: (1) Are TSH levels...

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Biomarkers
Major Depressive Disorder
Phenotype
Suicide, Attempted
Thyrotropin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40828484
DOI: 10.1007/s40618-025-02687-1
PMCID: PMC13053577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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