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Article

Association of polygenic risk for cannabis use disorder with brain structure among youth with and without bipolar disorder.

Journal of psychopharmacology (Oxford, England) - 1 Sept 2026

Sultan Alysha A, Zai Clement C, Kennedy Kody G, Young L Trevor, MacIntosh Bradley J, Goldstein Benjamin I

Abstract excerpt

BACKGROUND: Cannabis use disorder (CUD) is common in youth, with elevated rates among youth with bipolar disorder (BD). Cannabis use among youth is also associated with anomalous neurostructural phenotypes. While neurophysiological mechanisms associated with cannabis use may contribute to these differences, genetic predisposition to CUD may also be contributory. Given the lack of prior studies on this topic, we...

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PMID: 41755539
DOI: 10.1177/02698811261424206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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