Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence.

doi:10.1001/jamapsychiatry.2015.1131

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Article

Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence.

JAMA psychiatry - 1 Oct 2015

French Leon, Gray Courtney, Leonard Gabriel, Perron Michel, Pike G Bruce, Richer Louis, Séguin Jean R, Veillette Suzanne, Evans C John, Artiges Eric, Banaschewski Tobias, Bokde Arun W L, Bromberg Uli, Bruehl Ruediger, Buchel Christian, Cattrell Anna, Conrod Patricia J, Flor Herta, Frouin Vincent, Gallinat Jurgen, Garavan Hugh, Gowland Penny, Heinz Andreas, Lemaitre Herve, Martinot Jean-Luc, Nees Frauke, Orfanos Dimitri Papadopoulos, Pangelinan Melissa Marie, Poustka Luise, Rietschel Marcella, Smolka Michael N, Walter Henrik, Whelan Robert, Timpson Nic J, Schumann Gunter, Smith George Davey, Pausova Zdenka, Paus Tomáš

Abstract excerpt

IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk...

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Identifiers

PMID: 26308966
DOI: 10.1001/jamapsychiatry.2015.1131
PMCID: PMC5075969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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