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Article

Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents.

Behavior genetics - 1 Jul 2025

Kramer Sydney, Su Mei-Hsin, Stephenson Mallory, Rabinowitz Jill, Maher Brion, Roberson-Nay Roxann, Castro-de-Araujo Luis F S, Zhou Yi, Neale Michael C, Gillespie Nathan A

Abstract excerpt

Substance use has been associated with differences in adult brain morphology; however, it is unclear whether these differences precede or are a result of substance use substance use. We investigated the impact of polygenic risk scores (PRSs) for cannabis use disorder (CUD) and general substance use and substance use disorder liability (SU/SUD) on brain morphology in drug-naïve adolescents. Baseline data were used...

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Identifiers

PMID: 40711718
DOI: 10.1007/s10519-025-10227-z
PMCID: PMC12325389

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