Article
GSTT1 null genotype distribution in the Kumaun region of northern India.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Bag Arundhati, Upadhyay Saloni, Jeena Lalit M, Pundir Princi, Jyala Narayan S
Abstract excerpt
Glutathione S-transferases (GSTs) constitute a multigene family of multifunctional phase II metabolic enzymes. GSTT1, an important member of this group has a wide range of substrates including carcinogens. Total homozygous deletion or null genotype resulting in total lack of enzyme activity exists in populations for this enzyme. Since the null genotype may contribute to lower detoxification of carcinogens, this...
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