Article
Towards personalized vaccine repurposing for Alzheimer's prevention: genotype-specific protective association of the shingles vaccine with odds of Alzheimer's disease in participants of two large cohort studies.
BMC neurology - 25 Feb 2026
Duan Hongzhe, Ukraintseva Svetlana, Holmes Rachel, Wu Deqing, Yashkin Arseniy P, Akushevich Igor, Yashin Anatoliy, Arbeev Konstantin
Abstract excerpt
BACKGROUND: Our earlier study found that adult vaccination against shingles (herpes zoster infection caused by the reactivation of the varicella-zoster virus) was associated with significantly reduced risk of Alzheimer's disease (AD) later in life. Here, we investigated genotype-specific associations between the shingles vaccine and the odds of AD using data from the Health and Retirement Study (HRS) and the UK...
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