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Article

Allosteric activation of FGFR2 kinase in endometrial cancer: insights from Gaussian accelerated molecular dynamics and the Markov state model.

Physical chemistry chemical physics : PCCP - 11 Mar 2026

Mahapatra Subhasmita, Kar Parimal

Abstract excerpt

Endometrial carcinoma (EC) is one of the most prevalent gynaecological malignancies found in women. About 10%-12% of EC cases are caused by mutations in fibroblast growth factor receptor 2 (FGFR2). FGFR2 is a tyrosine kinase receptor involved in multiple biological processes such as cell proliferation, migration and homeostasis. N549K and K659E mutations of the FGFR2 kinase domain increase the basal kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41736675
DOI: 10.1039/d5cp04248h

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FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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