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Article

Revealing conformational changes of GTP-bound NRAS mutants probed by GaMD and Markov state models.

Physical chemistry chemical physics : PCCP - 25 Feb 2026

Zhao Lu, Wang Jian, Ping Haipeng, Yang Wanchun, Cao Haijun, Chen Jianzhong

Abstract excerpt

The RAS family proteins, including NRAS, are key regulators of intracellular signaling, acting as molecular switches that control essential cellular processes including proliferation and survival. Oncogenic NRAS mutations exert distinct effects on protein function. We employed Gaussian accelerated molecular dynamics simulations and Markov state models, complemented by principal component analysis and correlation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41660764
DOI: 10.1039/d5cp04245c

Genes

NRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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