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Article

Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.

Genetics - 6 May 2026

González-Castellano Inés, Quesada Humberto, Ramos-Onsins Sebastián, García-Dorado Aurora, Caballero Armando

Abstract excerpt

Overdominance (heterozygote advantage) for fitness is a form of balancing selection which supports the maintenance of genetic polymorphisms in the populations. This mode of selection is expected to generate a conspicuous footprint on neutral genetic variation in genomic regions of restricted recombination, which contrasts with the signature generated by other types of natural selection. In particular, gene...

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Identifiers

PMID: 41732107
DOI: 10.1093/genetics/iyag050
PMCID: PMC13147538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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