Alcohol use disorder and childhood adversity in the association between polygenic risk and suicidality.

doi:10.1016/j.jad.2026.122358

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Article

Alcohol use disorder and childhood adversity in the association between polygenic risk and suicidality.

Journal of affective disorders - 1 Dec 2026

Wu Victoria, Qin Xue-Jun, Ashley-Koch Allison, Kimbrel Nathan A, Gelernter Joel, Docherty Anna R, Kranzler Henry R, Feinn Richard, Davis Christal N

Abstract excerpt

OBJECTIVE: Suicidal ideation (SI) and suicide attempt (SA) are both influenced by genetic, behavioral, and environmental factors. Alcohol use disorder (AUD) and adverse childhood experiences (ACEs) may mediate or moderate the effects of genetic liability for suicidality. METHODS: Using data from 10,275 participants (43.8% female; 47.2% African-like genetic ancestry [AFR], 52.8% European-like genetic ancestry...

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Topics

Adult
Female
Humans
Male
Adverse Childhood Experiences
Alcoholism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genetic Risk Score

Multifactorial Inheritance

Risk Factors

Suicidal Ideation

Suicide, Attempted

White

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Identifiers

PMID: 42567209
DOI: 10.1016/j.jad.2026.122358

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