Effects of testosterone on gene expression in males and females across 40 human tissues.

Abstract excerpt

Variation in testosterone levels is associated with pronounced health risks, often in a discordant manner between males and females. While studies have demonstrated a sex-specific genetic architecture for testosterone, the biological basis for the differential impact on diseases between the sexes is largely unknown. In this study, we correlated predicted testosterone and within-sex gene expression measures across...

Topics

• Humans
• Male
• Female
• Testosterone
• Gene Expression Regulation
• Sex Characteristics
• Organ Specificity
• Gene Expression
• Gene Expression Profiling
• Genome-Wide Association Study
• Polymorphism, Single Nucleotide