Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-resolved NS5 stability predicts Japanese encephalitis virus fitness.

Virus genes - 1 Apr 2026

Thippeswamy Hariprasad, Ramesh Varsha, Suresh Kuralayanapalya Puttahonnappa, Hiremath Jagadish, Kamble Navnath, Palavesam Azhahianambi, Sengupta Pinaki Prasad

Abstract excerpt

Japanese encephalitis virus (JEV) remains a major health threat across Asia, yet the contribution of genotype-specific variation in the multifunctional NS5 protein to viral fitness is not fully resolved. This study evaluated how sequence differences among JEV genotypes G1-G5 shape NS5 stability and, in turn, replication potential. A unified in-silico workflow combined physicochemical profiling, residue-level...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Encephalitis, Japanese

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalitis Virus, Japanese

Share to Genotype

Share to Molecular Dynamics Simulation

Share to Protein Stability

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Identifiers

PMID: 41729434
DOI: 10.1007/s11262-026-02213-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-resolved NS5 stability predicts Japanese encephalitis virus fitness.PMID 41729434Read ↗

Globally defining the effects of mutations in a picornavirus capsidSemantic proximity Read ↗

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase InterfaceSemantic proximity Read ↗

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus ReplicationSemantic proximity Read ↗

Comparison of genotypes I and III in Japanese encephalitis virus reveals distinct differences in their genetic and host diversity.Semantic proximity Read ↗

Effective epitope identification employing phylogenetic, mutational variability, sequence entropy, and correlated mutation analysis targeting NS5B protein of hepatitis C virus: from bioinformatics to therapeutics.Semantic proximity Read ↗

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus ReplicationSemantic proximity Read ↗

The RNA-Binding Domain NS1 of Influenza as an Antiviral Target: From Evolutionary Conservation Mapping to Experimental Validation.Semantic proximity Read ↗

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability.Semantic proximity Read ↗

Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and ElongationSemantic proximity Read ↗

Structural and molecular investigation of the impact of S30L and D88N substitutions in G9R protein on coupling with E4R from Monkeypox virus (MPXV).Semantic proximity Read ↗

The mechanism by which P250L mutation impairs flavivirus-NS1 dimerization: an investigation based on molecular dynamics simulations.Semantic proximity Read ↗

Ketoamide resistance and hepatitis C virus fitness in val55 variants of the NS3 serine protease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.