Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and molecular investigation of the impact of S30L and D88N substitutions in G9R protein on coupling with E4R from Monkeypox virus (MPXV).

Journal of biomolecular structure & dynamics - 1 Feb 2025

Jin Yifan, Asad Gillani Syed Jawad, Batool Farah, Alshabrmi Fahad M, Alatawi Eid A, Waheed Yasir, Mohammad Anwar, Khan Abbas, Wei Dong-Qing

Abstract excerpt

Understanding the pathogenesis mechanism of the Monkeypox virus (MPXV) is essential to guide therapeutic development against the Monkeypox virus. In the current study, we investigated the impact of the only two reported substitutions, S30L, D88N, and S30L-D88N on the G9R of the replication complex in 2022 with E4R using structural modeling, simulation, and free energy calculation methods. From the molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Hydrogen Bonding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Protein Conformation

Share to Structure-Activity Relationship

Share to Thermodynamics

Share to Viral Proteins

Source

Identifiers

PMID: 38174700
DOI: 10.1080/07391102.2023.2291159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and molecular investigation of the impact of S30L and D88N substitutions in G9R protein on coupling with E4R from Monkeypox virus (MPXV).PMID 38174700Read ↗

Mutations in the monkeypox virus replication complex: Potential contributing factors to the 2022 outbreak.Semantic proximity Read ↗

The evolution of Monkeypox virus: a genetic and structural analysis reveals mutations in proteins involved in host-pathogen interactionSemantic proximity Read ↗

Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hot spots, functional patterns and molecule repurposing for monkey pox virusSemantic proximity Read ↗

Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hotspots, functional patterns, and molecule repurposing for monkeypox virus.Semantic proximity Read ↗

Monkeypox virus: phylogenomics, host-pathogen interactome and mutational cascade.Semantic proximity Read ↗

Computational rescue of antibody binding to monkeypox virus E8L: from electrostatic repulsion to salt bridge-enhanced affinity.Semantic proximity Read ↗

Deciphering the complete human-monkeypox virus interactome: Identifying immune responses and potential drug targetsSemantic proximity Read ↗

Immunoinformatic and molecular docking approaches: siRNA prediction to silence cell surface binding protein of monkeypox virusSemantic proximity Read ↗

The Hunt for antipox compounds against Monkeypox Virus Thymidylate Kinase and scaffolding protein leveraging Pharmacophore modeling, molecular docking, ADMET Studies, and molecular dynamics simulation studiesSemantic proximity Read ↗

Structural Insights into the Impact of the M142I Mutation in Monkeypox Virus G9 Protein on Subcomplex Formation Revealed by AlphaFold 3 Modeling.Semantic proximity Read ↗

Recently Added Frameshift Mutation in Human Monkeypox Virus (hMPXV) OPG191 Gene.Semantic proximity Read ↗

Bioinformatic investigation of Nipah virus surface protein mutations: Molecular docking with Ephrin B2 receptor, molecular dynamics simulation, and structural impact analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.