FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling.

Abstract excerpt

Gastrulation, a critical developmental stage involving germ layer specification and axes formation, is a major point of failure in human development, contributing to pregnancy loss and congenital malformations. However, due to ethical constraints and anatomical differences in animal models, the failure modes underlying human gastrulation remain poorly understood. To elucidate these failure modes, we introduce...

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