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Article

Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2017

Huang Ancheng C, Kautsar Satria A, Hong Young J, Medema Marnix H, Bond Andrew D, Tantillo Dean J, Osbourn Anne

Abstract excerpt

Sesterterpenoids are a rare terpene class harboring untapped chemodiversity and bioactivities. Their structural diversity originates primarily from the scaffold-generating sesterterpene synthases (STSs). In fungi, all six known STSs are bifunctional, containing C-terminal trans-prenyltransferase (PT) and N-terminal terpene synthase (TPS) domains. In plants, two colocalized PT and TPS gene pairs from Arabidopsis...

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PMID: 28673978
DOI: 10.1073/pnas.1705567114
PMCID: PMC5530694

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STS

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