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Article

A truncated mutation of MucA in Pseudomonas aeruginosa from a bronchiectasis patient affects T3SS expression and inflammasome activation.

Acta biochimica et biophysica Sinica - 25 Nov 2022

Liu Yanan, Du Lin, Zhu Yongzhang, Liu Xuefei, Zhou Ning, Li Congcong, Li Qingtian, He Ping

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic airway infection in bronchiectasis patients and is closely associated with poor prognosis. Strains isolated from chronically infected patients typically have a mucoid phenotype due to the overproduction of alginate. In this study, we isolate a P. aeruginosa strain from the sputum of a patient with bronchiectasis and find that a truncated...

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PMID: 36604139
DOI: 10.3724/abbs.2022169
PMCID: PMC9828237

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