Article
Distinct Metabolomic Signatures in Preclinical and Obstructive Hypertrophic Cardiomyopathy.
Cells - 29 Oct 2021
Schuldt Maike, van Driel Beau, Algül Sila, Parbhudayal Rahana Y, Barge-Schaapveld Daniela Q C M, Güçlü Ahmet, Jansen Mark, Michels Michelle, Baas Annette F, van de Wiel Mark A, Nieuwdorp Max, Levin Evgeni, Germans Tjeerd, Jans Judith J M, van der Velden Jolanda
Abstract excerpt
Hypertrophic Cardiomyopathy (HCM) is a common inherited heart disease with poor risk prediction due to incomplete penetrance and a lack of clear genotype-phenotype correlations. Advanced imaging techniques have shown altered myocardial energetics already in preclinical gene variant carriers. To determine whether disturbed myocardial energetics with the potential to serve as biomarkers are also reflected in the...
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