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Article

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer.

FEBS open bio - 1 Jul 2026

Tsui Long Wai, Hu Taobo, Husein Thomson Christian, Shek Wai Hei, Chen Bingrong, Wang Depeng, Wang Shu, Yu Weichuan, Fan Xiaodan, Long Mengping, Ishibashi Toyotaka

Abstract excerpt

ERαΔ7 is one of the most frequently observed splice variants of the ESR1 gene in breast cancer but its functions remain largely unknown. Here we report that ERαΔ7 predicted poor survival in luminal A type breast cancer from TCGA data. ERαΔ7 occurred more frequently in luminal type breast cancer, with expression inversely correlating with ESR1 expression. Functionally, ERαΔ7-expressing MCF-7 cells were found to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41703982
DOI: 10.1002/2211-5463.70215
PMCID: PMC13327064

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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