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How Protective are Nipple-Sparing Prophylactic Mastectomies in BRCA1 and BRCA2 Mutation Carriers?

Annals of surgical oncology - 1 Oct 2021

Garstka Meghan, Henriquez Anthony, Kelly Bridget N, Webster Alexandra, Khubchandani Jasmine A, Hughes Kevin, Nguyen Anvy, Oseni Tawakalitu, Specht Michelle, Coopey Suzanne B, Gadd Michele A, Smith Barbara L

Abstract excerpt

BACKGROUND: Nipple-sparing mastectomy (NSM) is now routinely offered to BRCA mutation carriers for risk reduction. We assessed the rates of ipsilateral cancer events after prophylactic and therapeutic NSM in BRCA1 and BRCA2 mutation carriers. METHODS: BRCA1 and BRCA2 mutation carriers undergoing NSM from October 2007 to June 2019 were identified in a single-institution prospective database, with variants of...

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PMID: 34296361
DOI: 10.1245/s10434-021-10445-9

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