Article
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
Nature genetics - 5 Jun 2011
Wu Chen, Hu Zhibin, He Zhonghu, Jia Weihua, Wang Feng, Zhou Yifeng, Liu Zhihua, Zhan Qimin, Liu Yu, Yu Dianke, Zhai Kan, Chang Jiang, Qiao Yan, Jin Guangfu, Liu Zhe, Shen Yuanyuan, Guo Chuanhai, Fu Jianhua, Miao Xiaoping, Tan Wen, Shen Hongbing, Ke Yang, Zeng Yixin, Wu Tangchun, Lin Dongxin
Abstract excerpt
Esophageal squamous-cell carcinoma (ESCC) is one of the most prevalent cancers worldwide and occurs at a relatively high frequency in China. To identify genetic susceptibility loci for ESCC, we conducted a genome-wide association study on 2,031 individuals with ESCC (cases) and 2,044 controls of Chinese descent using 666,141 autosomal SNPs. We evaluated promising associations in an additional 6,276 cases and...
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