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Article

Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2

15 Feb 2022

Abstract excerpt

The continuous emergence of SARS-CoV-2 variants highlights the need of developing vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representative SARS-CoV-2 strains carrying the hotspot mutations were selected. Then, guided by structural and computational analyses, we present a mutation-integrated trimeric form of spike receptor-binding domain...

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PMID: 35169113
DOI: 10.1038/s41421-022-00383-5

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