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Article

4-Hydroxybutyrate (4HB) released from poly-4-hydroxybutyrate scaffolds does not impact hallmark phenotypes of cancer in malignant or non-malignant breast cells.

Breast cancer research : BCR - 14 Feb 2026

Elahi Sakib F, Martin David P, Wan Yong, Zhang Li, Romero Daniela J, Kommeri Remya, Cramer Madeline C, Reavie Linsey, Mercer Adam C, Ardila Diana Catalina, Hussey George S, Badylak Stephen F

Abstract excerpt

BACKGROUND: Poly-4-hydroxybutyrate (P4HB) scaffolds are increasingly used to reinforce soft tissue during implant-based reconstruction after mastectomy. P4HB undergoes hydrolytic degradation to a natural metabolite, 4-hydroxybutyrate (4HB). Understanding the direct effects of 4HB on cancer cells is essential for assessing the oncologic safety of P4HB scaffolds used in breast reconstruction surgery. The aim of...

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Identifiers

PMID: 41691265
DOI: 10.1186/s13058-026-02234-7
PMCID: PMC13001300

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P4HB
MB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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