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Article

β-Hydroxybutyrate promotes chemoresistance and proliferation in breast cancer cells

28 Aug 2025

Abstract excerpt

Breast cancer is the most prevalent cancer among women, posing significant challenges due to its heterogeneity. Recent studies suggest that the ketogenic diet (KD) may enhance chemotherapy efficacy by modulating cancer cell metabolism, particularly through the elevation of ketone bodies like β-hydroxybutyrate (BHB). This study investigates the effects of BHB on breast cancer cells using both 2D and 3D culture...

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Identifiers

PMID: 40917722
DOI: 10.1016/j.bbrep.2025.102217

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