Article
The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis.
The Lancet. Microbe - 1 Apr 2022
Walker Timothy M, Miotto Paolo, Köser Claudio U, Fowler Philip W, Knaggs Jeff, Iqbal Zamin, Hunt Martin, Chindelevitch Leonid, Farhat Maha, Cirillo Daniela Maria, Comas Iñaki, Posey James, Omar Shaheed V, Peto Timothy Ea, Suresh Anita, Uplekar Swapna, Laurent Sacha, Colman Rebecca E, Nathanson Carl-Michael, Zignol Matteo, Walker Ann Sarah, Crook Derrick W, Ismail Nazir, Rodwell Timothy C
Abstract excerpt
Background: Molecular diagnostics are considered the most promising route to achieving rapid, universal drug susceptibility testing for Mycobacterium tuberculosiscomplex (MTBC). We aimed to generate a WHO endorsed catalogue of mutations to serve as a global standard for interpreting molecular information for drug resistance prediction. Methods: A candidate gene approach was used to identify mutations as...
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