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Article

Combining Mendelian randomization and experimental approaches for the identification of miRNAs related to major depressive disorder.

Journal of affective disorders - 15 Jun 2026

Cao Linlin, Sundquist Kristina, Zhang Yujie, Memon Ashfaque A, Hedelius Anna, Li Ning, Ji Jianguang, Sundquist Jan, Zheng Deqiang, Wang Xiao

Abstract excerpt

BACKGROUND: A growing body of evidence links microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal nature of these associations remains unclear. OBJECTIVES: This study aimed to investigate the potential causal association between miRNAs and MDD by combining Mendelian Randomization (MR) analyses and experimental validation. METHODS: Single-nucleotide polymorphisms (SNPs) significantly...

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PMID: 41690636
DOI: 10.1016/j.jad.2026.121394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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