Article
Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity.
Nature communications - 12 Feb 2026
Chang Richard C, Egusquiza Riann J, Amato Angélica Amorim, Li Zhuorui, Dougherty Alivia L, To Kaitlin T, Avila Michelle, Joloya Erika M, Wheeler Hailey B, Nguyen Angela, Shioda Keiko, Odajima Junko, Lawrence Michael S, Shioda Toshi, Blumberg Bruce
Abstract excerpt
Effects of prenatal environmental exposures can be transmitted across generations through the germline without DNA mutations, an example of transgenerational epigenetic inheritance. Understanding how such inheritance occurs remains a central unanswered question in biology. Here we show that gestational exposure of mice to the environmental obesogen tributyltin produces heritable changes in chromatin interactions...
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