Article
Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice.
Nature communications - 8 Dec 2017
Chamorro-Garcia Raquel, Diaz-Castillo Carlos, Shoucri Bassem M, Käch Heidi, Leavitt Ron, Shioda Toshi, Blumberg Bruce
Abstract excerpt
Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. Here we show that exposure of F0 mice to the obesogen tributyltin (TBT) throughout pregnancy and lactation predisposes unexposed F4 male descendants to obesity when dietary fat is increased. Analyses of body fat,...
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