Article

Heritable changes in chromatin contacts linked to transgenerational obesity

2022-10-29

Abstract excerpt

Burgeoning evidence demonstrates that responses to environmental exposures can be transmitted to subsequent generations through the germline without DNA mutations 1,2 . This is controversial because underlying mechanisms remain to be identified. Therefore, understanding how effects of environmental exposures are transmitted to unexposed generations without DNA mutations is a fundamental unanswered question in bio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7aa40f46-9005-5bd5-b9ce-304e09928b64
DOI: 10.1101/2022.10.27.514145

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heritable changes in chromatin contacts linked to transgenerational obesityDOI 10.1101/2022.10.27.514145Read

Heritable changes in chromatin contacts linked to transgenerational obesitySemantic proximity Read

Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity.Semantic proximity Read

Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in miceSemantic proximity Read

Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice.Semantic proximity Read

Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure.Semantic proximity Read

Transgenerational effects of obesogensSemantic proximity Read

Transgenerational inheritance of BPA-induced obesity correlates with transmission of new CTCF sites in the Fto geneSemantic proximity Read

Epigenetic germline inheritance of diet-induced obesity and insulin resistance.Semantic proximity Read

Phenotypic cross-species conservation and cross-generation directionality switching in epigenetic inheritanceSemantic proximity Read

Paternal obesity and epigenetic inheritance of breast cancer: The role of systemic effects and transmission to the second generationSemantic proximity Read

Transgenerational metabolomic fingerprints in mice ancestrally exposed to the obesogen TBTSemantic proximity Read

Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposuresSemantic proximity Read