Article
HIV and placental infection modulate the appearance of drug-resistant Plasmodium falciparum in pregnant women who receive intermittent preventive treatment.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jan 2011
Menéndez Clara, Serra-Casas Elisa, Scahill Michael D, Sanz Sergi, Nhabomba Augusto, Bardají Azucena, Sigauque Betuel, Cisteró Pau, Mandomando Inacio, Dobaño Carlota, Alonso Pedro L, Mayor Alfredo
Abstract excerpt
BACKGROUND: Factors involved in the development of resistance to sulphadoxine-pyrimethamine (SP) by Plasmodium falciparum, particularly in the context of intermittent preventive treatment during pregnancy (IPTp), are not well known. We aimed to determine the impact of IPTp and human immunodeficiency virus (HIV) infection on molecular markers of SP resistance and the clinical relevance of resistant infections....
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