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Article

High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581.

PloS one - 1 Jan 2009

Gesase Samwel, Gosling Roly D, Hashim Ramadhan, Ord Rosalynn, Naidoo Inbarani, Madebe Rashid, Mosha Jacklin F, Joho Angel, Mandia Victor, Mrema Hedwiga, Mapunda Ephraim, Savael Zacharia, Lemnge Martha, Mosha Frank W, Greenwood Brian, Roper Cally, Chandramohan Daniel

Abstract excerpt

BACKGROUND: Sulphadoxine-pyrimethamine (SP) a widely used treatment for uncomplicated malaria and recommended for intermittent preventive treatment of malaria in pregnancy, is being investigated for intermittent preventive treatment of malaria in infants (IPTi). High levels of drug resistance to SP have been reported from north-eastern Tanzania associated with mutations in parasite genes. This study compared the...

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Identifiers

PMID: 19238219
DOI: 10.1371/journal.pone.0004569
PMCID: PMC2644264

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Source receipt: pubmed, retrieved 7 Sept 2026.

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