Article
An Achilles' heel for methicillin-resistant Staphylococcus aureus? Re-evaluating β-lactam susceptibility of MRSA.
Antimicrobial agents and chemotherapy - 5 Aug 2026
Petersiel Neta, Howden Benjamin P, Giulieri Stefano, Tong Steven Y C
Abstract excerpt
Methicillin-resistant Staphylococcus aureus (MRSA) infections (i.e., carrying the mec gene) are challenging to treat due to their inherent resistance to most antistaphylococcal β-lactams. Given the poor outcome of severe MRSA infections and limitations of the current approved treatments, there is growing interest in repurposing β-lactams as part of a treatment strategy for these infections. Here, we review the...
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