Article
Identification and Potential Regulatory Properties of Evolutionary Conserved Regions (ECRs) at the Schizophrenia-Associated MIR137 Locus.
Journal of molecular neuroscience : MN - 1 Oct 2016
Gianfrancesco Olympia, Griffiths Daniel, Myers Paul, Collier David A, Bubb Vivien J, Quinn John P
Abstract excerpt
Genome-wide association studies (GWAS) have identified a region at chromosome 1p21.3, containing the microRNA MIR137, to be among the most significant associations for schizophrenia. However, the mechanism by which genetic variation at this locus increases risk of schizophrenia is unknown. Identifying key regulatory regions around MIR137 is crucial to understanding the potential role of this gene in the aetiology...
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