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Schizophrenia risk-associated SNPs affect expression of microRNA 137 host gene: a postmortem study.

Human molecular genetics - 8 Nov 2024

Feng Ningping, Mandal Ajeet, Jambhale Ananya, Narnur Pranav, Chen Gang, Akula Nirmala, Kramer Robin, Kolachana Bhaskar, Xu Qing, McMahon Francis J, Lipska Barbara K, Auluck Pavan K, Marenco Stefano

Abstract excerpt

Common variants in the MicroRNA 137 host gene MIR137HG and its adjacent gene DPYD have been associated with schizophrenia risk and the latest Psychiatric Genomics Consortium (PGC). Genome-Wide Association Study on schizophrenia has confirmed and extended these findings. To elucidate the association of schizophrenia risk-associated SNPs in this genomic region, we examined the expression of both mature and immature...

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PMID: 39239979
DOI: 10.1093/hmg/ddae130

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