Adverse karyotype amplifies risk in secondary acute myeloid leukemia (AML) and AML with myelodysplasia-related changes.

doi:10.1080/16078454.2026.2628479

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Adverse karyotype amplifies risk in secondary acute myeloid leukemia (AML) and AML with myelodysplasia-related changes.

Hematology (Amsterdam, Netherlands) - 1 Dec 2026

Matsukawa Toshihiro, Yoshida Shota, Onozawa Masahiro, Fujii Fumiaki, Nagai Jun, Takahashi Tomoki, Ota Shuichi, Hashiguchi Junichi, Mori Akio, Miyagishima Takuto, Ibata Makoto, Kakinoki Yasutaka, Oyake Tatsuo, Yamamoto Satoshi, Hayashi Toshiaki, Wakasa Kentaro, Saga Tomoyuki, Igarashi Tetsuya, Iyama Satoshi, Tsutsumi Yutaka, Fujimoto Katsuya, Adachi Masaaki, Yoshida Masahiro, Hashimoto Daigo, Teshima Takanori

Abstract excerpt

BACKGROUND: Secondary acute myeloid leukemia (sAML) and AML with myelodysplasia-related changes (AML-MRC) are associated with poor prognosis, but the impact relative to de novo AML remains controversial. We investigated clinical and genetic features in a multicenter Japanese cohort before CPX-351 approval. METHODS: We retrospectively analyzed 294 patients with newly diagnosed AML registered in the Hokkaido...

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PMID: 41666291
DOI: 10.1080/16078454.2026.2628479

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TP53
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