Article
Mutations and prognosis in myelodysplastic syndromes: karyotype-adjusted analysis of targeted sequencing in 300 consecutive cases and development of a genetic risk model.
American journal of hematology - 1 May 2018
Gangat Naseema, Mudireddy Mythri, Lasho Terra L, Finke Christy M, Nicolosi Maura, Szuber Natasha, Patnaik Mrinal M, Pardanani Animesh, Hanson Curtis A, Ketterling Rhett P, Tefferi Ayalew
Abstract excerpt
To develop a genetic risk model for primary myelodysplastic syndromes (MDS), we queried the prognostic significance of next-generation sequencing (NGS)-derived mutations, in the context of the Mayo cytogenetic risk stratification, which includes high-risk (monosomal karyotype; MK), intermediate-risk (non-MK, classified as intermediate/poor/very poor, per the revised international prognostic scoring system;...
Topics
- Aged
- Aged, 80 and over
- Female
- Humans
- Karyotype
- Male
- Models, Genetic
- Mutation
- Myelodysplastic Syndromes
- Prognosis