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Article

sic1 mutation leads to rDNA instability by partial duplication with SIR4.

Nucleic acids research - 5 Feb 2026

Murai Taichi, Yanagi Shuichi, Hori Yutaro, Yamamuro Yoshio, Kobayashi Takehiko

Abstract excerpt

The ribosomal RNA gene cluster (rDNA) in Saccharomyces cerevisiae consists of about 150 tandem copies, making it a fragile site prone to copy number changes through recombination among the repeat. While extensive research has been conducted to understand the mechanisms for rDNA stability maintenance, the relationship between the stability maintenance of rDNA and other genomic regions remains unclear. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Identifiers

PMID: 41665005
DOI: 10.1093/nar/gkag096
PMCID: PMC12887534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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