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Article

Sir2 regulates stability of repetitive domains differentially in the human fungal pathogen<i>Candida albicans</i>

1 Jul 2016

Abstract excerpt

DNA repeats, found at the ribosomal DNA locus, telomeres and subtelomeric regions, are unstable sites of eukaryotic genomes. A fine balance between genetic variability and genomic stability tunes plasticity of these chromosomal regions. This tuning mechanism is particularly important for organisms such as microbial pathogens that utilise genome plasticity as a strategy for adaptation. For the first time, we...

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PMID: 27369382
DOI: 10.1093/nar/gkw594

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