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Article

Genetic variability in thrombopoietin receptor and GATA1 influences response to eltrombopag in dengue-induced thrombocytopenia.

Scientific reports - 9 Feb 2026

Sayem Mohammad, Rimon Razoan Al, Alam Saruar, Saba Abdullah Al, Sanyal Mousumi, Sayem Mohammad, Tabassum Chowdhury Tamanna, Amin Md Robed, Chakraborty Sajib, Kabir Ahmedul, Nabi A H M Nurun

Abstract excerpt

Integrating pharmacogenetic studies into clinical trials enhances personalized medicine by identifying genetic variations that influence drug efficacy and safety. Eltrombopag, a thrombopoietin receptor agonist, has shown efficacy in treating thrombocytopenia associated with various conditions, including dengue fever, though variability in patient response remains poorly understood. This study investigates the...

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Benzoates
Dengue
GATA1 Transcription Factor
Genetic Variation
Hydrazines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Thrombopoietin

Thrombocytopenia

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Identifiers

PMID: 41663574
DOI: 10.1038/s41598-026-37871-7
PMCID: PMC12953650

Genes

GATA1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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